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Tibor Valyi-Nagy, professor of pathology, director of neuropathology at UIC and research collaborator on the study. The immune system requires inflammation to constantly fight off the virus, and neurons have some degree of damage because of this continuous immune response, according to Dr. “We think we will have data to show other viruses, such as Epstein-Barr, Kaposi’s sarcoma, varicella-zoster, are all going to share this mechanism because they share homologous proteins,” Shukla said.īecause the herpesvirus sits in neurons forever, there is speculation it is connected to neurodegenerative diseases. Some of those issues could include neurodegenerative disorders, which researchers believe further research may show. When you don’t have it, you have issues,” said Chandrashekhar Patil, also a co-author of the study and a visiting scholar at UIC’s department of ophthalmology and visual science. OPTN is needed to signal an influx of proper immune cells at the site of infection. “The study also shows there is an impairment of immune response when there is a deficiency in OPTN.
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“Where you have mutated OPTN plus herpes, you have the recipe to create a disaster in terms of neurodegeneration,” Shukla said. Additional studies are being planned to examine naturally occurring mutations in OPTN, such as the ones reported in glaucoma and ALS patients, and how they may affect neuronal health and HSV-1 infection, Shukla explained. This shows there is a faster degeneration of neurons when OPTN is not there. The virus growth was much higher in the brains of animals without OPTN, killing local neurons and eventually leading to animal death. The researchers believe the results from this study will apply to all eight different human herpesviruses.įor the study, mice with removed OPTN genes were infected with ocular HSV-1.
That has meaning for other viruses as well,” Shukla said. The autophagy that happens is very selective. “OPTN stops the virus from growing and it stops it by autophagy - engulfing the virus particles inside tiny vesicles called autophagosomes. The new research suggests why HSV-1 is suppressed: OPTN, a conserved autophagy receptor, selectively targets HSV-1 proteins to degradation by autophagy, explained Tejabhiram Yadavalli, a co-author of the study and visiting scholar at UIC’s department of ophthalmology and visual science. However, in most individuals, the virus is suppressed during a primary infection before it can significantly damage the central nervous system. Herpesviruses naturally infect the central nervous system and can result in degenerative brain and eye disorders, as well as encephalitis. Researchers sought to discover why HSV-1 can become fatal for individuals who are immunocompromised but not for healthy individuals.
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My good friend Seth from Nerd Enterprises also has videos to show How to Link to a Tweet – (which he does slightly differently I noticed) and also How to link to a Post on Google Plus. You will also find he does many Quickbooks and Excel Tutorials which are useful too.Members of the OPTN research team, from left: Chandrashekhar Patil, Tejabhiram Yadavalli, Dr. I can’t think of any others that you might need right now but if there is another link you are trying to find please ask below and if I know I will tell you if not I will find out, and still tell you! How to find the direct link or URL of a YouTube VideoĪgain there are many ways – if the link isn’t at the top of the page you are viewing from then go to the video and click SHARE – you don’t have to share but it will bring up the link in a separate box.
Statigram is a great way to view pictures or photos to like and comment on too.
#Get direct url from tumblr video Pc
There are many ways to do this but if you are on the PC you can log in with Statigr.am – you simply click the picture that you want the link from. How to find the direct link or URL on Instagram
Click this and it will take you to the new page which has the URL. Find the post that you need the link from – and the same as Facebook, find the time-stamp.Ģ. How to find the direct Link or URL to a Google Plus post.ġ. Although pledges are still welcome to help with funding. This one was actually to celebrate the fact that project forgive had reached their goal of $100.000 dollars. The post will open in its own window with its direct link. Underneath your name you will see a time/date stamp – click that.ģ. Go to your Facebook Wall – timeline – find the post you want to retrieve the URL of.Ģ. The post then opens up with its own link at the top of the page.ġ. Hover over the top right hand corner, you will see that the corner curls up, click this.ģ. Find the post you want on your dash board by clicking your name first.Ģ.
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